N5315 Advanced Pathophysiology Inflammation, Altered Immunity and Infection Core Concepts Objectives with Advanced Organizers Immune System 1. Examine the structure and function of the immune system. a. Evaluate how the normal function of T-lymphocyte and B-lymphocyte cells differ. b. Differentiate between the function of humoral and cell mediated immunity. c. Analyze the difference between active acquired immunity and passive acquired immunity. d.Define the following terms:
2. Analyze the process and purpose of the primary and secondary immune responses. Primary-initial exposure to antigen; w/in 5-7 days, rise of IgM, later a rise of IgG Secondary- next exposure to antigen, anamnestic, IgM and IgG levels rise much more Aging and the Immune System 3. Examine the age-related changes which occur in the immune system Decreases with age, after 60- decreased T-cell activity Middle age-thymus only 15% of max size; decreased T-cell differentiation B-cells produce less antibodies, decrease amount of memory B-cells, increase circulating autoantibodies 4. Evaluate the physiologic differences in fetal and neonatal immune function.
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- Fall '15