N5315 Advanced Pathophysiology
Inflammation, Altered Immunity and Infection
Core Concepts Objectives with Advanced Organizers
Immune System
1.
Examine the structure and function of the immune system.
a.
Evaluate how the normal function of T-lymphocyte and B-lymphocyte cells differ.
b.
Differentiate between the function of humoral and cell mediated immunity.
c.
Analyze the difference between active acquired immunity and passive acquired
immunity.
d.Define the following terms:
2.
Analyze the process and purpose of the primary and secondary immune responses.
Primary-initial exposure to antigen; w/in 5-7 days, rise of IgM, later a rise of IgG
Secondary- next exposure to antigen, anamnestic, IgM and IgG levels rise much more
Aging and the Immune System
3.
Examine the age-related changes which occur in the immune system
Decreases with age, after 60- decreased T-cell activity
Middle age-thymus only 15% of max size; decreased T-cell differentiation
B-cells produce less antibodies, decrease amount of memory B-cells, increase circulating
autoantibodies
4.
Evaluate the physiologic differences in fetal and neonatal immune function.
