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N5315 Advanced PathophysiologyInflammation, Altered Immunity and Infection Core Concepts Objectives with Advanced Organizers Immune System1.Examine the structure and function of the immune system. a.Evaluate how the normal function of T-lymphocyte and B-lymphocyte cells differ.b.Differentiate between the function of humoral and cell mediated immunity. c.Analyze the difference between active acquired immunity and passive acquired immunity. d.Define the following terms:
2.Analyze the process and purpose of the primary and secondary immune responses.Primary-initial exposure to antigen; w/in 5-7 days, rise of IgM, later a rise of IgGSecondary- next exposure to antigen, anamnestic, IgM and IgG levels rise much more Aging and the Immune System 3.Examine the age-related changes which occur in the immune systemDecreases with age, after 60- decreased T-cell activityMiddle age-thymus only 15% of max size; decreased T-cell differentiationB-cells produce less antibodies, decrease amount of memory B-cells, increase circulating autoantibodies4.Evaluate the physiologic differences in fetal and neonatal immune function.