Antiserum Preparations.pptx - Neeraj Paliwal Antiserum Preparations \u2022 Antitoxic sera(Antitoxins \u2022 Antibacterial sera \u2022 Antiviral sera Neeraj

Antiserum Preparations.pptx - Neeraj Paliwal Antiserum...

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Neeraj Paliwal Neeraj Paliwal Antiserum Preparations Antitoxic sera (Antitoxins) Antibacterial sera Antiviral sera Neeraj Paliwal L21– L23 & T7 May 16 th – May 24 th , 2019. AIMST University, Malaysia.
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Neeraj Paliwal Introduction Antisera Antibody containing serum fraction obtained from pathogen exposed individual(s) Individual(s) could be – i) Human, or ii) Animal (generally Horse) Sera (Serum) Whole Blood devoid of RBCs & Clotting Factors (fibrinogen & thrombin) Serum = Whole Blood – (RBCs + clotting factors)
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Neeraj Paliwal From & for? Generally, antisera are derived from animals The active immunity of the animal is artificially stimulated by providing antigenic exposure In few diseases such as Measles and German Measles ; which can not be reproduced in animals ( due to non- susceptibility ); human serum or products derived from it, are used Antisera are used for providing passive immunity as these possess antibodies
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Neeraj Paliwal What is what? Immunity - Active / Passive IMMUNITY NATURAL (Constitutional) * ACQUIRED (Added during Lifetime) ACTIVE (developed and lost slowly ) Naturally Acquired After clinical or subclinical Infection Artificially Stimulated Antigen containing preparations (Vaccines) PASSIVE (produced and lost quickly ) Naturally Obtained From Mother (Antibodies) Artificially Produced Antibody containing preparations ( Sera or human IgG )
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Neeraj Paliwal Blood Fractions The blood is withdrawn for isolation of blood components to collect individual blood fractions, which are – Plasma Blood cells (RBCs, WBCs, platelets, etc.) Serum Clotting Factors (fibrinogen, thrombin) Specific Immunoglobulin(s)
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Neeraj Paliwal Plasma Vs Serum Plasma: cell-free liquid part of blood which can be observed or harvested after treating the whole blood with anticoagulant(s) (un-clotted blood ) Serum: liquid part of blood which can be observed or harvested after coagulation of the whole blood (clotted blood ) “Serum is free from RBCs & clotting factors V s
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Neeraj Paliwal Purpose Exposed or immunized animal/human develops antibodies against pathogen or toxic substance(s) Collected serum or sera is used for prophylaxis or for immediate counter control purposes Prophylaxis : immediate but temporary protection e.g. Tetanus or Gas Gangrene Antitoxins Spores of Clostridia may infect patient after injuries in anaerobic conditions, in such cases Tetanus antitoxin provides temporary protection Therapeutic use : immediate life saving e.g. Botulinum, Venoms or Diphtheria Antitoxins Due to severe or acute nature of infection, high quantity of appropriate antitoxin may save the life Hence, also known as immune sera
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Neeraj Paliwal Basic Types Based on antibodies’ combating nature, these are classified as: A. Antitoxic sera (Antitoxins) B. Antibacterial sera C. Antiviral sera Antitoxins neutralizes exotoxins Antibacterial sera combat against endotoxin producing bacteria Antiviral sera combat against viruses Antitoxic Sera (Antitoxins) are found to be far more effective than antibacterial or antiviral sera
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  • passive immunity, blood plasma, Neeraj Paliwal

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