PHARMACOLOGICAL TREATMENT OF DEEP VEIN THROMBOSIS (DVT) ROBERT VEROS NSG 6005 SOUTH UNIVERSITY ONLINE
DEEP VEIN THROMBOSIS • A thrombus (blood clot) that attaches and remains in the wall of a vessel. • A DVT normally refers to a thrombus formation in a large vessel, usually of the lower extremities. • They are more prevalent in venous circulation due to lower pressure. • Approx. 900,000 venous thrombosis events (VTEs) occur annually. • Approx. 1/3 have been fatal (McCance, 2014)
DEEP VEIN THROMBOSIS RISK FACTORS • There are three factors known as the triad of Virchow that attribute to DVTs. • Damage to the endothelial • Trauma • Medications • Venous stasis • Obesity • Immobility (hospitalization, bedridden) • Leg dependency for prolonged amount of time (long trips)
DEEP VEIN THROMBOSIS RISK FACTORS • Venous stasis cont. • Age • Heart Failure • Hypercoagulable disorders • Malignancy • Genetic disorders • Oral contraceptives and hormonal replacement therapy • Pregnancy • Anti-phospholipid syndrome (McCance, 2014)
CLINICAL MANIFESTATIONS • Clotting factors and platelet aggregation lead to thrombus formation. • Further platelet aggregation growth continues due to inflammation around the clot. • If clot grows and causes obstruction to the vessel impeding blood flow. • Causing Edema • Redness • Pain • Ulceration (McCance, 2014)
PHARMACOLOGICAL TREATMENT OF DVT • Anticoagulants • Heparin and Low-Molecular-Weight Heparins (LMWH) • Heparin • Dalteparin • Enoxaparin • Tinzaparin • Fondaparinux • Warfarin (Woo & Robinson, 2015)
PHARMACOLOGICAL TREATMENT OF DVT • Antiplatelets • Aspirin • Clopidogrel • Tricagrelor • Ticlopidine • Rivaroxaban
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- Fall '16