Case Study #1This scenario involves a patient whose initials are AO and has a history of obesity. Recently the patient has gained nine pounds and newly diagnosed with hypertension and hyperlipidemia. Current medications taken by patient are as follows: Atenolol 12.5 mg daily, Doxazosin 8 mg daily, Hydralazine 10 mg daily, Sertraline 25 mg daily and Simvastatin 80 mg daily.Patient Factor: BehaviorThe factor chosen for this scenario is behavior. The case study does not mention the patient’s race, gender or age so the most appropriate factor that can influence the problem of obesity is behavior. This patient most likely has a lifestyle of eating poorly and being non-active in daily living. When a person is overweight, medication is affected due to the way it’s distributed within and excreted, therefore dosages will need to be calculated depending on their lipophilicity (Barras & Legg, 2017). Obese patients often have sleep apnea due to excess weight so monitoring these patient for side effects on certain medications are important. They are at risk for respiratory depression and airway obstruction when medicated with narcotics and sedatives, so knowing the pharmacokinetics and pharmacodynamics for obesity is vital (Nickson, 2015). Pharmacokinetics and Pharmacodynamics Impacting Drug TherapySince the patient is obese there are certain factors that will impact the way the drug interacts within the body. Volume of distribution is important when deciding the loading dose of the patient as well as clearance to decide the maintenance dose. The body of a normal weight person has a ratio of 4:1 of lean weight to adipose weight where an obese person has a ratio of 3:2. When it comes to drug clearance the lean weight is what is calculated as adipose weight has
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- Summer '15