1 CBLG311 - S2019- Lecture 1 (2).pptx - CBLG311 Cell Biology S2019 Professor Dr Roberto Botelho 1 Cells moving(migrating to repair a wound MDCK cell

1 CBLG311 - S2019- Lecture 1 (2).pptx - CBLG311 Cell...

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CBLG311: Cell Biology S2019 Professor: Dr. Roberto Botelho 1
MDCK cell monolayer undergoing wound closure. Image courtesy of Assaf Zaritsky and Doron Kaplan. Cells moving (migrating) to repair a wound 2
Image courtesy of George von Dassow, Koen J.C. Verbrugghe, Ann L. Miller, Jenny R. Sider, William M. Bement (J Cell Biol. 2009 Dec 14;187(6):831-45.) Cell Division 3
Section 1 : Introduction to Cell Biology Section 1 : Introduction to Cell Biology Reference reading (6e) : Chapter 1: pgs: 1-15; 24-28; Chapter 2: pgs: 43-50; 51-55; 57; 60-66; Panel 2-1, 2-2, 2-3, 2-7; Chapter 3: pg. 109-119; 134-136; 143-158; 1.Key concepts about cells Chemical information DNA replication Transcription and types of RNAs Translation Cellular Energy 2.Prokaryotes vs. eukaryotes : what are they and their differences 3.Evolution of eukaryotic cells 4.Chemical composition of cells Small molecules Macromolecules (types, diversity) Macromolecule Types Shape determines function 5. Protein folding and structure Amino acids and polypeptides Ligand-protein interactions kinases, phosphatase and GTPases 4
WHAT IS CELL BIOLOGY? The study of the cell occurs at many levels: Molecular composition and organization Subcellular structure and organization Function of the individual components of the cell Cell differentiation and function Communication between environment and cells Cell replication 5 What? Where? How?
TO UNDERSTAND CELLS: A modern cell biologist understands and uses: Molecular genetics Recombinant DNA and genetic engineering Biochemistry Genomics and proteomics Systems biology Bioinformatics Advanced microscopy and imaging 6
What’s a Cell? The smallest unit of life. Inside the cell: Order and structure Inside the cell: Order and structure The non- living world Plasma membrane: Separates the living from non- living worlds Nutrients, Energy, information 7
Some universal properties of cells The __________________ delineates the cell and controls the exchange and communication with the non-living world that surrounds the cell. The inside of the cell is ordered or disordered? ________________ Cells ________________ to form two new cells: continuation of life This is possible because of the genetic code stored chemically as DNA The DNA code is faithfully replicated by ___________________ The DNA encodes discreet units of of information: _________________ Genes are ______________ into discreet molecules: RNA RNA is then ________________ into proteins , which are the workhorses of the cell. Reference reading : Chapter 1, pages 1-11 8
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