Neural circuit worksheet Answers.pdf

Neural circuit worksheet Answers.pdf - Biology 361 Neural...

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Biology 361 Neural connections, long term potentiation, and pattern generator worksheet Long term potentiation 1. This mechanism relies on two different glutamate receptors expressed in the post-synaptic neuron, AMPA and NMDA. List two major differences between these two glutamate receptors. AMPA is a Na + channel. NMDA is a non-specific cation channel (Na + /Ca 2+ ) NMDA is blocked by Mg 2+ ; AMPA is not 2. How do these two glutamate receptors result in strengthening a synapse? Draw a quick sketch, to explain how long term potentiation can happen. Glutamate binds to both receptors. AMPA allows Na + to pass; NMDA is blocked by Mg 2+ . High frequency APs keep the AMPA receptor open long enough; depolarization surpasses E Mg2+ . Mg 2+ is dislodged from NMDA Ca 2+ enters the cell, acts through calmodulin kinase II to increase sensitivity of AMPA. Next release of glutamate will have larger effect. Paracrine signal increases likelihood that pre-synaptic cell will release more glutamate. Next pre-synaptic AP will have larger release of glutamate.
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  • Fall '13
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