2019SummerMoodle 2a Cell physiology basicsx - Cell Physiology Basics 1 The structure and function of a multicellular organism depends on the

2019SummerMoodle 2a Cell physiology basicsx - Cell...

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Cell Physiology: Basics 1
The structure and function of a multicellular organism depends on the structural and functional characteristics of its cells Cell Theory Cells are the basic unit of life All living organisms are composed of cells All cells come from pre-existing cells “Omnis cellula e cellula” ~ Rudolph Virchow (but actually plagiarized…) The success of each cell as a whole depends on the integrated function of many discrete membrane bound organelles (functional compartmentalization) 2 *Reading assignment: Lucey et al 2009
The plasma membrane provides a selectively permeable barrier between the intracellular and extracellular environment Phospholipid bilayer provides primary barrier function Membrane proteins function in selective permeability, signal transduction, cell-cell interaction, anchor to ECM and cytoskeleton, etc. 3 Campbell NA, Reece JB. Biology . 7 th ed. San Francisco CA: Benjamin Cummings, 2005. p 127.
Review of pertinent basics: The hydrophobic effect A system will spontaneously move towards a state of equilibrium where energy is at a minimum and entropy is at a maximum The aggregation of non-polar molecules in an aqueous environment is a thermodynamically favorable process driven by entropy! Spontaneous self-assembly of biomolecules Phospholipid formation of micelles, liposomes, and bilayers are the most thermodynamically stable state depending on ration of phospholipid to water Protein native structure is most thermodynamically favorable state for the given polypeptide chain 4 Lodish H et al. Molecular Cell Biology. 5 th ed. New York: W.H. Freeman, 2004. p 35 and 45.
Modes of Membrane Transport 5 Moyes CD, and Schulte PM. Principles of Animal Physiology . San Francisco: Pearson Benjamin Cummings, 2006. p 85.

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