Ford_PPT_Ch_07(1).ppt - Introduction to Clinical Pharmacology Chapter 7 Antibacterial Drugs That Disrupt the Bacterial Cell Wall Copyright \u00a9 2014

Ford_PPT_Ch_07(1).ppt - Introduction to Clinical...

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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Introduction to Clinical Pharmacology Chapter 7 Antibacterial Drugs That Disrupt the Bacterial Cell Wall Introduction to Clinical Pharmacology Chapter 7 Antibacterial Drugs That Disrupt the Bacterial Cell Wall
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Group of antibiotics for treatment of susceptible pathogens Actions: Cell wall synthesis; DNA or RNA synthesis; protein synthesis There are four groups of penicillins: (1) natural penicillins, (2) penicillinase-resistant penicillins, (3) aminopenicillins, and (4) extended-spectrum penicillins Introduction to Penicillins
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Receive culture and sensitivity report Select antibiotic to which the microorganism is sensitive To minimize risk of bacteriostatic activity, ensure adequate blood level of penicillin in the body Identifying the Appropriate Penicillin: Sensitivity and Resistance
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Used against infectious diseases Used as initial therapy for any suspected staphylococcal infection Prescribed as prophylaxis Potential secondary bacterial infection Potential infection in high-risk patients On a continuing basis to those with rheumatic fever or chronic ear infections Uses
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Drug resistance becomes an issue when: Antibiotics are regularly used by a patient A group of people live in close proximity Bacteria: Naturally resistant or acquired resistance to drug, such as MRSA Emergence of a new resistance associated with bacteria that have both a natural and an acquired resistance ability Resistance to Drugs
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Gastrointestinal reactions Hypersensitivity reactions Anaphylactic shock Cross-sensitivity/cross-allergenicity Superinfections: Bacterial; fungal Hematopoietic changes Adverse Reactions
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Contraindicated in patients with history of hypersensitivity to penicillin or the cephalosporins Use cautiously in patients with renal disease, asthma, bleeding disorders, gastrointestinal disease, pregnancy or lactation, history of allergies Reason for caution: Any indication of sensitivity Contraindications and Precautions
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Interactions Interactant drug Effect of interaction with penicillin Oral contraceptives Decreased effectiveness Tetracyclines Decreased effectiveness Anticoagulants Increase bleeding risks Beta-adrenergic blocking drugs May increase the risk for an anaphylactic reaction
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Introduction to Cephalosporins Introduction to Cephalosporins Effective in the treatment of all strains of
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