Ford_PPT_Ch_12(1).ppt - Introduction to Clinical Pharmacology Chapter 12 Antifungal and Antiparasitic Drugs Copyright \u00a9 2014 Wolters Kluwer Health |

Ford_PPT_Ch_12(1).ppt - Introduction to Clinical...

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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Introduction to Clinical Pharmacology Chapter 12 Antifungal and Antiparasitic Drugs Introduction to Clinical Pharmacology Chapter 12 Antifungal and Antiparasitic Drugs
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Antifungal Drugs: Actions and Uses Antifungal Drugs: Actions and Uses Fungicidal OR fungistatic: Action is related to their concentration in body tissues Used prophylactically to prevent fungal infection in immunocompromised patients Used to treat superficial and deep fungal infections; systemic infections; superficial infections of nail beds and oral, anal, and vaginal areas
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Helminthic and Protozoal Infections and Amebiasis Helminthic and Protozoal Infections and Amebiasis Helminthic infections: Invasion of body by parasitic worms Anthelmintic drugs kill the parasites Protozoal infections: Single-cell parasites Antiprotozoal drugs work to inhibit DNA synthesis, effectively killing the organism Amebiasis is a parasitic gastrointestinal disorder
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Antifungal Drugs: Adverse Reactions Antifungal Drugs: Adverse Reactions Topical administration: Integumentary reactions Irritation and burning sensation; redness, stinging; abdominal pain (vaginal preparations) Systemic administration Headache; rash; nausea; vomiting; diarrhea; anorexia and malaise; abdominal, joint, or muscle pain
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Antifungal Drugs: Contraindications, Precautions, and Interactions Antifungal Drugs: Contraindications, Precautions, and Interactions Contraindicated in patients with a history of allergies to the drug; during pregnancy and lactation Contraindications for antifungal drugs: Griseofulvin; voriconazole; itraconazole Used cautiously in patients with renal dysfunction and/or hepatic impairment Interactions possible depending on the individual drugs, and many interactions can occur
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Nursing Process: Assessment Nursing Process: Assessment Preadministration assessment: Assess for signs of the infection before giving the first dose; take and record vital signs Inspect superficial fungal infections of the skin or skin structures and record Ask about pain and presence of white plaques or sore areas of the oral or perineal areas and any vaginal discharge
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Nursing Process: Assessment (cont.) Nursing Process: Assessment (cont.) Ongoing assessment: Carefully observe the patient every 2 to 4 hours for adverse drug reactions If administered topically, instruct the patient to look for signs of improvement and adverse reactions both minor and severe
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Nursing Process: Nursing Diagnosis
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