Epi752-14-Lecture-4---Standardization_6pp.pdf - Epidemiologic Methods 752 Epidemiologic Methods 2 340.752 Lecture 4 Today we will learn To compare

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Epidemiologic Methods 752 1 Lecture 4 Lecture 4: Standardization Stephan Ehrhardt, MD, MPH Associate Professor Epidemiologic Methods 2 340.752 Today we will learn: To compare apples and oranges … … by making both “bananas”. 2 Direct standardization” 3 Learning objectives for Lecture 4 To know: o Direct and indirect standardization (aka adjustment) of “rates” to control for confounding (by age) o What the key differences between the two methods are o When to use what method o Limitations of standardized rates as summary measures Use of the “rate” in vital statistics 4 From 751, you know “rates” with the denominator “person-time”. In vital statistics you may see: Rate: # of events/population * multiplier (10 n ) 5 Remember: Definitions and means to control for confounding Definitions 1. “Mixing of effects” 2. “Classical” definition 3. “Counterfactual” model _________________________________________________________ 4. Collapsibility definition Design and study conduct stage: Analysis stage: Restriction Matching Randomization Adjustment: - Standardization - Stratified analysis - Multiple regression Control for confounding 6 Direct standardization
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