Psychology final project.docx - deDiego 1 Lani deDiego...

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deDiego 1Lani deDiego Professor IannacconePsychology-ECH10/18/17CCL11 Biomarker and its Relation toPsychology
deDiego 2Abstract This research paper uses articles and outside research, specific to degenerative diseases, to propose the concept of the diagnoses of Chronic Traumatic Encephalopathy(CTE) before death as opposed to after. Diagnosis, up to today's date has only been able to be done after death. However, in using past research, specialists know from the analysis of PET scans, that tau protein levels are higher in patients with CTE and specifically are different from other degenerative diseases like Alzheimer's. This difference allows CTE to stand alone in diagnosis. Researchers can now hypothesize that using CCL11 as a biomarker will allow CTE to be flaggedand diagnosed before death; improving an individual's quality of life. IntroductionChronic Traumatic Encephalopathy(CTE) is a degenerative disease originally found in football players. However, “hockey players, wrestlers, soldiers, and even people who participate in lower-impact sports, such as soccer and rugby, can also develop this disease”(Ghose 2015). People around the world have been diagnosed with CTE post-mortem; due to repetitive brain injuries during their careers. Unfortunately, this degenerative brain disease has typically been identified via autopsy after the death of the patient. Recently research has been conducted that has added to our understanding of CTE and there may be ways of diagnosis before death. Autopsies have shown a significantly higher ratio of the protein CCL11 in the brain and cerebrospinal fluid (CSF). This protein can be measured through a medical technique called ELISA and would give doctors the opportunity to identify the disease before death. Is diagnosis before death a real possibility?
deDiego 3Background The word “concussion” comes from the Latin word concussionem and it is defined as a mild form of traumatic brain injury (TBI). These injuries are due to jarring, impact, fall, or something of that nature, which causes the head to move rapidly in a back and forth motion. This rapid motion of the head results in the soft tissue of the brain to come into contact with the skull, resulting in bruising at the point of contact. The jarring is usually followed by a temporary or prolonged loss of some functions. Side effects and severity of a concussion depend fully on the individual as well as the type of motion and amount of force that caused the injury. Concussions are deemed “mild” brain injuries because they are not usually life threatening. Some of the common symptoms are headaches, difficulty with speech and memory, sensitivity tolight and sound, irritability, and depression. However, multiple concussions and repetitive asymptomatic subconcussive hits to the head can cause other, more serious, side effects as well as degenerative diseases. This is referred to as “Chronic Traumatic Encephalopathy, which is a

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