Autoimmunity Notes.docx - Ch 14 – Lewis Autoimmunity pg...

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Ch. 14 – Lewis Autoimmunity pg. 217 Autoimmunity Immune system no longer differentiates self from non-self. Autoantibodies and auto-sensitized T cells cause pathophysiologic tissue damage. - (1) Inheritance, (2) auto-reactivity by triggers [infections] Autoimmune Dz tend to cluster: more than one autoimmune disease [RA, Addison’s] -Same family genetic predisposition [certain human leukocyte (HLA) types] even in genetic predisposed trigger is required. Viruses type 1 diabetes mellitus -Streptococcal infection and group A B-hemolytic streptococci Rheumatic fever and rheumatic heart Drugs Hemolytic anemia methyldopa (Aldomet) administration Lupus-like syndrome procainamide (Pronestyl) Gender and hormones Women Autoimmune Diseases Organ-specific and systemic illnesses Systemic lupus erythematosus (SLE) -Women 20-40years -Loss of self-tolerance for the body’s own DNA antigens -Tissue injury r/t antinuclear antibodies cell membrane is damaged and DNA is released into
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  • Spring '17
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