hypersensitivity notes.docx

hypersensitivity notes.docx - Ch 14 – Lewis pg 209...

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Ch. 14 – Lewis pg 209 Hypersensitivity Altered Immune Response Hypersensitivity Reactions Overactive immune response r/t foreign antigens or against itself. Autoimmune disease body fails to recognize self-proteins & reacts against self-antigens. Classified: 1. Source of antigen, 2. Time sequence, 3. Basic immunologic mechanisms causing the injury. Types I, II, III immediate & humoral immunity Types IV delayed r/t cell-mediated immunity Type I: IgE-Mediated Reactions Anaphylactic highly sensitized to specific allergens IgE produced in response to allergen attach to mast cells and basophils. (potent chemical mediators histamine, serotonin, leukotrienes, eosinophil chemotactic factor for anaphylaxis [ECF-A], kinins & bradykinin) 1 st exposure IgE antibodies produced & bind Subsequent exposures IgE bound to cells triggers degranulation of the cell & release of chemical mediators Mediators attack target tissue allergy symptoms o Smooth muscle contractions mediators short-acting and reversible o vascular permeability o vasodilation o hypotension o secretion of mucus o itching *inherited trait sensitized to an allergen. Ex: asthmatic father son w/ allergic rhinitis Local Wheal & Flare Reaction Pale wheal containing edematous fluid surrounded by a red flare from the hyperemia (minutes – hours not dangerous) ex: mosquito bite Dx: during skin test Anaphylaxis Mediators released systemically injection, sting w/i minutes life threatening branchial constriction & airway obstruction & vascular collapse. initial manifestations edema & itching @ site shock rapid, weak pulse, hypotension, dilated pupils, dyspnea, & cyanosis (possibly) PLUS bronchial edema & angioedema Death if emergency treatment not initiated.
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Ch. 14 – Lewis pg 209 Hypersensitivity
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  • Spring '17
  • Acevedo
  • Allergic rhinitis, Histamine, Contact dermatitis, Atopic dermatitis

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