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prelim 2 takenote notes

prelim 2 takenote notes - NIACIN-high amount causes...

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NIACIN- -high amount causes flushing -made from tryptophan, inefficient bc 60 g tryp make 1 g niacin -humans require 15 mg/day -mild deficiency causes: tiredness, weakness, poor memory, cant concentrate -severe deficiency- PELLAGRA- 3 D’s Dermatitis, diarrhea, dementia -lil niacin in corn and molasses.. corn soaked in lime water (calcium hydroxide) inc the available niacin -MEGADOSES- 1000-1500 mg/day: -lowers serum triglycerides, lowers VLDL, raises HDL, inc sensitivity to insulin receptors, but found that smaller doses effective But, megadoses can cause liver damage, and visual problems (dec vision, eyelid edema, loss of eyebrow or eyelashes) -sources: make it in body, meat, mushrooms, asparagus, legumes(beans), fish FLAVINOIDS- 1. FNM-flavin mononuclotide 2. FAD-flavin adenin dinucleotide 3. CRITICAL in producing ATP come from RIBOFLAVIN (vitamin B2) 1. need little of it (1-2 mg/day) 2. lots of food with it, deficiencies are rare, only if genetic 3. riboflavin in just about everything-yogurt, meat, milk, collard greens 4. if ppl ingest lots of food containing flavinoids, display less cancer than those who eat less - doesnt prevent cancer though -maybe ppl who eat riboflavin are healthier in general, eat less meat, and have healthier lifestyles THIAMIN- VITAMIN B1 1. required in the conversion of pyruvate to Acetyl CoA 2. without thiamin, pyruvate doesnt go into the mitochondria as acetyl CoA, it gets
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