Chapter_02.pptx - Chapter 2 Drugs and the Body Copyright...

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Chapter 2:
Drugs and the Body
Chapter 2:
Drugs and the Body

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Pharmacodynamics
Pharmacodynamics

Pharmacodynamics is the science of dealing with
interactions between living organisms and foreign
chemicals.

Each living system has chemical reactions occurring
continuously in the body.

When other chemicals (drugs) are added to the body
other effects occur.

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Drug Action
Drug Action

Replace or act as a substitute for missing chemicals

To increase or stimulate certain cellular activities

To depress or slow cellular activities

To interfere with the functioning of foreign cells

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Receptor Sites
Receptor Sites

Receptor sites react to certain chemicals to cause an
effect within the cell.

Agonists

Noncompetitive antagonists-

Competitive antagonists

Drug- enzyme interactions

Selective toxicity

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Lock and Key
Lock and Key

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Pharmacokinetics #1
Pharmacokinetics #1

The study of absorption, distribution, metabolism
(biotransformation), and excretion of drugs

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Pharmacokinetics #2
Pharmacokinetics #2

Onset of drug action

Drug half-life

Timing of the peak effect

Duration of drug effects

Metabolism or biotransformation of the drug

Site of excretion

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Pharmacokinetics #3
Pharmacokinetics #3