week 4 notes.docx - Chapter 13 The metabolism of cell...

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Chapter 13: The metabolism of cell growth and proliferationWhy is metabolism important to an understanding of cancer?
even in the presence of oxygen glycolysis converts 1 molecule of glucose to 2 molecules of pyruvate which generates 2 molecules each of ATP and NADHCancer Cell Metabolism Videometabolism of cell growth and proliferationocancer cells proliferate abnormally and excessivelyconsume a lot of nutrients to keep ofoemployed in the PET-based diagnosismonitoring of cancer based on the rate of glucose uptake by tumor cellsonon-proliferating cells extract ATP from glucose, fatty acids and AA through the mitochondrial TCA cycle and oxidative phosphorylationoproliferating cells require a lot more macro nutrients this requiressubstratesoglucose and glutamine being most significantoATPoNADPHFor redox balanceoGlycolysis is a major source of ATP for cancer cellsoRegulation of metabolism Balance anabolism and catabolism Uptake of glucose and glutamineRapid catabolism and aerobic glycolysisNutrient uptake is regulated by GF or hormones depending on cellular

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