Oral Antidiabetic Agents Med Chart.docx - Chapter 51 Oral Antidiabetic Agents Increases insulin secretion Metformin alone \u2013 glucose production by the

Oral Antidiabetic Agents Med Chart.docx - Chapter 51 Oral...

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Chapter 51: Oral Antidiabetic Agents 1 ST GENERATION SULFONYLUREAS (-amide) chlorpropamide (Diabinese) – use w/ caution in elderly 2 ND GENERATION SULFONYLUREAS (G- -ide) glimepriride (Amaryl) Increases insulin secretion Administer: 30 mins before meals Have 10-15g carb ready S/E : hypoglycemia, weight gain, sulfa allergy, skin reaction (1 st gen.)   risk for hypoglycemia: elderly and renal insufficiency Monitor : s/s of hypoglycemia, glucose levels, urine ketones If taken with beta blockers, may mask signs of hypoglycemia Drug-Drug Interactions: NSAIDS, warfarin, sulfonamides Instruct to avoid alcohol BIGUANIDES metformin (Glucophage, Fortamet) metformin with glyburide (Glucovance) Metformin alone glucose production by the liver Combo – also increases body tissues’ sensitivity to insulin Administer: with food to decrease GI distress S/E: lactic acidosis, hypoglycemia IF combined   risk of hypoglycemia if used alone Monitor:
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  • Spring '19
  • weight gain, lactic acidosis,  S,  Monitor,  Administer

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