Nov 30, 2006 - Regulation of transcription Another form of...

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Regulation of transcription Another form of transcription regulation Nucleosome binding acetylation and methylation DNA blocking by nucleosome binding o Transcription factors are unable to bind to a romoter site while tightly bound in a nucleosome DNA acetylation o Adding acetyl compounds to amino acids to loosen DNA from nucleosomes so transcription factors can bind DNA methylation o Adding methyl compounds to cytosine to block accidental transcription of “turned off” genes Post-transcriptional Control in Eukaryotes In general, involves regulatory proteins and small RNA molecules that recognize specific sequences in mRNA transcripts and synthesized proteins o Pre-mRNA splicing o Passage of mRNA from nucleus into cytoplasm o Destruction of mRNA in cytoplasm o Translation o Phosphorylation of proteins o Targeting proteins for destruction Chapter 19 Early Development
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Nov 30, 2006 - Regulation of transcription Another form of...

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