ADstimulants - ANTIDEPRESSANTS Development began in the...

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Unformatted text preview: ANTIDEPRESSANTS Development began in the early 1950s in TB Wards Iproniazid Tricyclics Developed ANTIDEPRESSANTS TRICYCLICS: Similar to Phenothiazines MECHANISM OF ACTION: BLOCKS REUPTAKE OF NOREPINEPHRINE AND SEROTONIN MOOD REFLECTS A BALANCE BETWEEN NOREPINEPRINE AND SEROTONIN EFFECTS OF TRICYCLICS ELEVATION IN MOOD INCREASED PHYSICAL ACTIVITY INCREASED MENTAL ALERTNESS INCREASED APPETITE INCREASED ABILITY TO SLEEP EXAMPLES OF TRICYCLICS TOFRANIL ELAVIL IMPACT OF TRICYCLICS TREATS DEPRESSION 60-70% OF STUDIES CLOSE IN EFFECT TO ECT SELECTIVE SEROTONIN REUPTAKE INHIBITORS NEWER ANTIDEPRESSANTS INTRODUCED IN 1987 EFFECTS SEROTONIN PROZAC SAFER THAN TRICYCLICS WEIGHT LOSS SIDE EFFECT SOME REPORTS OF VIOLENT/SUICIDAL BEHAVIOR Most popular Antidepressant Used for depression and obsessive- compulsive disorders, and panic disorders Approved for use with children PAXIL The most heavily advertised antidepressant drug between 1999- 2003. Excellent patient response-59% believed that the drug was beneficial Paxil negtive responses include-21% felt drowsiness or disorientation-53% experienced decreased sexual interest-22% gained weight FDA has concerns that children taking Paxil are 3.2 times more likely to attempt suicide PaxilCR PaxilCR is a derivative of Paxil with a a positive patient response especially for social anxiety disorder, panic disorder and premenstrual syndrome....
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ADstimulants - ANTIDEPRESSANTS Development began in the...

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