exam 1 rev. condenced

exam 1 rev. condenced - Fluid secretion from salivary...

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Fluid secretion from salivary acinar cells is a good example of epithelial transport Largely driven by Cl - gradient Secondary transporters in basolateral domain concentrate Cl - 5x in cytoplasm compared to electrochemical gradient (equilibrium) Cl - leaves through ion channels in apical domain (Na + follows paracellularly)
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RAB protiens Mediate vessicular fusion Vessicular protiens that provide some specificity in delivery They are G protiens
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miscelanious tyrosine kinase /MAP kinase pathway Controls cell proliferation , importantly involved in cancer Muscle contraction (PKA path) G-protein coupled receptors muscarinic and adrenergic receptors(gpcr’s) Gap junctions in cardiac and smooth muscle Inhibitory potentials more effective with gap junctions V. gated Ca++ channels in synaptic terminal for snare activation T. synaptic snares have docked and primed states nAchR is Ionotropic mAchR hyperpolarizes heart rete decrease
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nAchR allows cations (no anions) of all types Mostly Na+ K + near equilibrium-no driving force Ca ++ is 4X slower (diffusion constant) than Na ++
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What is the function of the beta sub unit in activating K+ channel in the heart? Gs adenalyl cyclase cAMP PKA Beta adrenergic receptors heart contraction, smooth muscle contractions, secretion of saliva PROTIENS (PKA phosphorelation of snares) Cholera and cAMP regulation » Gs stuck open adenalyl cyclase excess cAMP CFTR activation Cl exits from CFTR activation Gi – ion channels…. and cAMP inhabition Gq – IP3 and DAG …IP3 Ca++… Muscle Salivary FLUID secretion via muscarinic input
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Nuclear receptors Sex and nutrients Gene expression Map/ Ras /tyrosine kinase RTK Ras (G protien) kinase cascade transcription activator meitosis….(cancer) Ras is a GTPase like alpha unit
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Cyclic AMP GPCR(Gs) adenalyl cyclase (membrane protien) cAMP some kinase
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This note was uploaded on 03/31/2008 for the course PSL 431 taught by Professor Stephenson during the Spring '07 term at Michigan State University.

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exam 1 rev. condenced - Fluid secretion from salivary...

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