Chapter_51.ppt - Chapter 51 Diuretic Agents Copyright \u00a9 2013 Wolters Kluwer Health | Lippincott Williams Wilkins Classes of Diuretics \u2022 Thiazide and

Chapter_51.ppt - Chapter 51 Diuretic Agents Copyright...

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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 51: Diuretic Agents Chapter 51: Diuretic Agents
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Classes of Diuretics Classes of Diuretics Thiazide and Thiazide-like Diuretics Loop Diuretics Carbonic Anhydrase Inhibitors Potassium-Sparing Diuretics Osmotic Diuretics
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Function of Diuretic Agents Function of Diuretic Agents Increase the amount of urine produced by the kidneys Increase sodium excretion
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Indications for Diuretic Use Indications for Diuretic Use Edema associated with congestive heart failure Acute pulmonary edema Liver disease (including cirrhosis) Renal disease Hypertension Conditions that cause hyperkalemia
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Sites of Action of Diuretics Sites of Action of Diuretics
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Use of Diuretic Agents Across the Lifespan Use of Diuretic Agents Across the Lifespan
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Thiazide and Thiazide-Like Diuretics Thiazide and Thiazide-Like Diuretics Hydrochlorothiazide ( HydroDIURIL ) Chlorothiazide ( Diuril ) Bendroflumethiazide ( Naturetin ) Benzthiazide ( Exna ) Hydroflumethiazide ( Diucardin ) Methyclothiazide ( Aquatensen ) Polythiazide ( Renese ) Trichlormethiazide ( Diurese )
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Thiazide and Thiazide-Like Diuretics (cont.) Thiazide and Thiazide-Like Diuretics (cont.) Actions Action is to block the chloride pump Keeps chloride and the sodium in the tubule to be excreted in the urine, thus preventing the reabsorption of both in the vascular system Indications Treatment of edema associated with CHF, liver, or renal disease Monotherapy or adjuncts for the treatment of hypertension
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Thiazide and Thiazide-Like Diuretics (cont.) Thiazide and Thiazide-Like Diuretics (cont.) Pharmacokinetics Well absorbed for the GI tract, metabolized in the liver and excreted in the urine. Contraindications Allergy to thiazides or sulfonamides Fluid and electrolyte imbalances, and renal and liver disease Bipolar disorders Pregnancy and lactation
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Thiazide and Thiazide-Like Diuretics (cont.) Thiazide and Thiazide-Like Diuretics (cont.) Caution Gout Systemic lupus Diabetes Hyperparathyroidism Adverse Effects Related to interference with the normal regulatory mechanisms of the nephron Hypokalemia Lithium
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