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List differential diagnosis that would help confirm GERD while ruling out other diagnosis. Which medication is the best medication for treatment of GERD and why? What labs or other diagnostic tests that are used to confirm GERD? Gastroesophageal Reflux Disease is the reason for over six million ambulatory care visits yearly. GERD is synonymous with acid reflux. Gastroesophageal reflux disease (GERD) is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus or beyond, into the oral cavity (including larynx) or lung (Badillo, 2014). GERD presents in a wide variety of symptoms, one of the most common is substernal burning sensation that radiates upward. These symptoms can mimic those of angina or a myocardial infarction. GERD can be dangerous for those patients that have night time reflux which has the potential to initial aspiration or bronchospasm. Other symptoms include sore throat, chronic cough, dysphagia, and Due to the vague symptoms of GERD,