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GeneExp3_08 - Gene Expression 4 1 a b c d Eukaryotic Gene...

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Gene Expression 4 1. Eukaryotic Gene Transcription a. Promoters b. RNA Polymerases c. Pre-Initiation Complex Formation d. DNase Footprinting 2. PEPCK Gene Regulation PEPCK Promoter How does Glucagon/cAMP Regulate this Promoter? cAMP Signal Transduction Cascade Coactivators Chromatin Remodeling How do Glucocorticoids Regulate this Promoter? Nuclear Receptors How does Insulin Regulate this Promoter?
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Transcription Regulation in Eukaryotes Differences from prokaryotes: Chromatin limits access of regulatory proteins to promoters Factors must reorganize the chromatin In addition to promoters, eukaryotic genes have ‘enhancers’, also known as upstream activation sequences DNA bending permits multiple proteins to bind to multiple DNA sequences
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Pol II Initiation Occurs at TATA box within the Promoter
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How Are Genes Transcribed in Eukaryotes? RNA polymerases I, II and III transcribe rRNA, mRNA and tRNA genes, respectively All 3 are big, multimeric proteins (500-700 kD)
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