LazzeriniDenchiSuppFigLegends.doc

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Supplemental Figure 1. Transient DNA damage response in TRF2 null hepatocytes. ( A ) Immunhistochemistry for the detection of g-H2AX in liver sections of Mx-Cre TRF2 F/- mice either untreated or at the indicated time following pI-pC administration. (B) IHC for BrdU in the liver sections of Mx-Cre TRF2 F/- mice either untreated, 6 days following pI-pC administration or, as positive control, 72 hours following partial hepatectomy. BrdU was administered 12 hours before harvest. (C) Immunoblot for Rap1 (1252) in liver extracts of Mx-CRE TRF2 F/- mice either untreated or treated with pI- pC at the indicated time prior to harvest. (D) Immunoblot for phosphorylated p53 (Ser18) and total p53 (AI-125) in liver extracts of Mx-CRE TRF2 F/- mice either untreated or treated with pI-pC at the indicated time prior to harvest. Spleen extracts derived from untreated and irradiated (4 Gy and 10 Gy) mice were used as positive controls for p53 induction. Supplemental Figure 2. Persistence of TRF2 deleted hepatocytes one month
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  • Fall '19
  • BrdU, Mx-Cre TRF2F

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