Bi_233_ch26_fluid__electrolyte__and_acid-base_balance_part_2.pdf

This preview shows page 1 - 5 out of 13 pages.

Chapter 26: Fluid, Electrolyte, and Acid-Base Balance1Regula’on of CalciumCalcium in ECF is important for:Blood clo5ngNeurotransmi9er release inaxon terminalsDevelopment of bones andteeth99% of calcium is found inbone and teethCa++ in ICFNeeded for muscle contracConand nerve conducConRegula’on of Calcium and PhosphatePTH increases blood calcium levels bytargeCng:Bones – acCvates osteoclasts to breakdown bone matrixAnd decreases osteoblast acCvitySmall intesCne – enhances intesCnalabsorpCon of calciumKidneys – enhances calcium reabsorpConand decreases phosphate reabsorpConAnd decreased secreCon of Ca++AcCvaCon of calcitrolVitamin D
Chapter 26: Fluid, Electrolyte, and Acid-Base Balance2Influence of CalcitoninFrom thyroid C cellsReleased in response to rising blood calcium levelsHumoral controlNegaCve feedbackAntagonist to PTHCalcium LevelsNormal: 9.8 ‐ 10.1 mEq/LHypocalcemia:< 8.9 md/dLIncreases excitabilityCauses muscle tetanyDue to acute pancreaCCsHypercalcemia:> 10.1 mEq/LInhibits neurons and muscle cellsDue to hyperparathyroidism
Chapter 26: Fluid, Electrolyte, and Acid-Base Balance3Regula’on of MagnesiumPrimarily an intracellular electrolyte50% in bone, rest in cellsContributes to protein synthesisNecessary for ATP acCvity and synthesisATP usually actually Mg‐ATPTypically involved in binding of anion substrate to acCve site inmost enzymesNeuromuscular funcConsLow Mg++Increased irritability and hyperexcitability of CNSHigh Mg++Depression of CNS ‐ may lead to comaRegula’on of MagnesiumMay cause arrhythmiaRegulaCon of Mg++balanceIncreased excreCon due to increased Ca++, increasedMg++, increased ECF volume, low PTHValuesNormal: 1.5 ‐ 2.5 mEq/LHypomagnesaemia < 1.5 mEq/LDue to malnutriConHypermagnesaemia > 2.5 mEq/LFrom renal failure
Chapter 26: Fluid, Electrolyte, and Acid-Base Balance4Acid‐Base BalanceNormal pH of body fluids 7.35 ‐ 7.45Arterial blood is 7.4Venous blood and intersCCal fluid is 7.35Intracellular fluid is 7.0

Upload your study docs or become a

Course Hero member to access this document

Upload your study docs or become a

Course Hero member to access this document

End of preview. Want to read all 13 pages?

Upload your study docs or become a

Course Hero member to access this document

Term
Spring
Professor
BJ Page
Tags
pH, alkalosis, respiratory acidosis, Metabolic Acidosis

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture