ESKAPE Pathogens.pptx

ESKAPE Pathogens.pptx - ESKAPE Pathogens Payton Harris...

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ESKAPE Pathogens Payton Harris Brittney Mcdonald Ethan Petrey
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“No ESKAPE” Pathogens that were believed to have been conquered during the golden age of antbiotcs are now reemerging in drug resistant forms and doing so at an acceleratng rate. As a result, we are effectvely running out of treatment optons. Hospitals have become havens for mult- drug resistant “superbugs,” and the widespread misuse of antbiotcs in households across the world means that drug- resistant pathogens are emerging as a threat in our very homes. The process of acquiring resistance remains elusive and is an important area of ongoing research, but the trends we see today point to a grim future if we do not find the right biotechnological and pharmaceutcal solutons.
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Introductio n The “ESKAPE” pathogens (E. faecium, S. aureus, K. pneumoniae, A. baumanii, P. aeruginosa and Enterobacter species) are common causes of nosocomial infectons, “escaping” the effects of antbacterial drugs. Vancomycin resistant Enterococci (VRE) are of partcular concern due to a very limited range of actve antmicrobials. Daptomycin is the only available cidal drug for such isolates however daptomycin non- susceptbility is now emerging and in lieu of the availability of any novel agents combinaton therapy is an attractve opton. Recent in vitro work has suggested potental synergy for combinatons of daptomycin with aminoglycosides1 and beta- lactams2, however experience of daptomycin in combinaton with the glycycline agent tgecycline is lacking.
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ESKAPE pathogens are a THREAT The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa,
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  • Fall '19
  • daptomycin, Enterococcus faecium, Acinetobacter baumannii, infectons

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