Lecture 14 second part Biology 2

Lecture 14 second part Biology 2 - Lecture 16: Immune...

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1 Lecture 16: Immune System 2 The Immune System I. Response to Invasion A. The invaders B. Response to invaders 1. Innate Immunity (Non-specific) Lines of defense 2. Acquired Immunity (Specific) Humoral response Cell-mediated response III. Human health and the immune system 3 What does the immune system do? • FUNDAMENTAL CHALLENGES – Defense: keep the bad guys out • Bacteria, viruses, & multicellular parasites Æ DESTROY • Multiple lines of defense – Precision warfare • Differentiate self from “non-self” • Differentiate healthy self from “infected self” Æ DESTROY • Prevent re-infection • One of most sophisticated and elaborate organ systems in the body
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4 The Bad Guys 1. “Free-living” Function by damaging body tissue and releasing enzymes or toxins that affect cells and organs. E.g., Borrelia (Lyme), Yersinia (Plague), Strep, anthrax 5 The Bad Guys 2. Not free-living. Must invade a host cell (intracellular). Can lead to cellular damage or death. Use cell molecular machinery to replicate themselves E.g., HIV, influenza, rabies, HPV, etc. 6 The Bad Guys 3. e.g., protists, flukes, tapeworms, malaria, nematodes, ticks, etc.
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Organs of the Immune System Bone marrow—Site of origin of all blood cells (B cells mature here) Lymph nodes—Trap foreign molecules, contain white blood cells Spleen—Filter for blood Thymus—T cells mature here Leukocytes—general term for white blood cells 8 Prerequisite: Recognizing Self • Useless unless differentiate between friends and enemies • Enemy #1: antigens • Major histocompatibility complex (MHC) – Proteins expressed on cell surfaces – SUPER diverse family of genes • No two people alike – How animals “smell” offspring and relatives 9 Two Types of Immunity 1. Provides general protection against any micro- organism that enters the body. -- Broad spectrum 2. Allows the organism to resist a specific pathogen after exposure. -- Targeted destruction
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This note was uploaded on 03/31/2008 for the course EBIO 1220 taught by Professor Demig-addams during the Spring '07 term at Colorado.

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Lecture 14 second part Biology 2 - Lecture 16: Immune...

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