From the last study guide:
List 4 effects that metabolites of arachidonic acid have on the inflammatory
Upon completion of the unit on immunity the student should be able to:
Define antigen and antibody.
Antigen – “non self” cell, usually a protein (best), > 40,000 MW, repetitive
epitopes, multiple epitopes; epitope – the part of the component that is recognized
Types of responses:
Shared – Heterologous
Endogenous – Autologous – these are the host’s own normal constituents
which, normally, are recognized as “self”.
They do not elicit an immune
response, a state known as tolerance.
Exogenous – Homologous – Known as iso-antigens and are the
determinants that distinguish the tissue components of one individual from
Their expression is genetically controlled.
Antibody - in the operational sense they are molecules binding specifically to
appropriate antigen (biologic effect, complement (c’) activation, opsinization,
neutralization of bacterial toxins); from the chemical point of view, antibody
activity of the plasma resides in the globulin fraction (immunoglobulins)
Differentiate between a humoral and cellular immune response based on cell type
involved and rate of response to antigen challenge.
Humoral – antibody production (B lymphocytes recognize antigen, present
antigen to T-cells, T-cells drive B-cells to plasma, plasma cells produce
Cellular immune – production of immunoglobulins reacting specifically with the
antigen (antibodies), proliferation of lymphocytes with a variety of other
List five different types of antibodies and state the cell type involved in their
G – gamma, most abundant, readily diffuses, can cross the placenta, is not good at
c’ activation, found in serum and tissues
A – alpha – found in secretions, inhibits adherence of coated microorganisms to
mucosal surfaces, it has two binding sites (dimer)