Lecture nineteen 11 19 08

Lecture nineteen 11 19 08 - 58 species are host to: C....

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C. Albicans 58 species are host to:
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Candida albicans Common inhabitant of Skin Mucous membranes Urogenital tract Gastrointestinal tract Limited by: Host immune system Co-occurring bacteria
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Bacterial growth inhibits yeast Antibiotics suppress bacteria Promote fungal infections
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Infection of oral cavity Thrush Most common in: premature infants Problems by Candida albicans
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C. albicans Genital infections Diabetes Pregnancy Antibiotic therapy Heart infections I.V. drug use High gut levels associated with behavioral problems 15% respond to anti-fungal therapy Risk factors Contaminated needles
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Treatment Nystatin Binds to ergosterol Fluconazole Inhibits ergosterol biosynthesis Cell membranes
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Ergosterol X Ergosterol is required for fungal cell membranes Nystatin binds to ergosterol Fluconazole prevents synthesis Animal cells do not have ergosterol Inside of cell Outside of cell
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All of these target ergosterol
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Systemic candidiasis No evidence this is a common problem Fungi work for me CDC: occurs in critically ill patients
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Single celled Cause of pneumonia Rare until late 1970s Pneumocystis jiroveci = PCP
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Affected gay men Fatal Led to discovery of AIDS PCP was the defining diagnosis for 63% of AIDS patients in 1987
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Lecture nineteen 11 19 08 - 58 species are host to: C....

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