Lecture twenty-one 11 24 08

Lecture twenty-one - Antibiotics Discovery Use in medicine 1928 England Alexander Fleming studied bacteria Bacterial cells Pure culture Fleming was

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Antibiotics Discovery Use in medicine
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Alexander Fleming studied bacteria 1928 England
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Bacterial cells Pure culture
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Fleming was also interested in bacterial art
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In 1928 Fleming took a long vacation
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Mold Contamination He returned to find many contaminated cultures
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FUNGAL COLONY INHIBITION ZONE BACTERIAL GROWTH 1928 Hypothesis: Fungal growth inhibits bacteria
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Spores Spore forming cells Penicillium chrysogenum
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Spores Spore forming cells Refined hypothesis: Penicillium chrysogenum inhibits Staphylococcus aureus
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Staphylococcus aureus P. chrysogenum Zone of inhibition A diffusible metabolite of P. chrysogenum might be responsible for the inhibition Experiment to test hypothesis
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“Mold juice” A diffusible metabolite of P. chrysogenum Zone of inhibition Staphylococcus aureus Next step: Identify the active ingredient
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Penicillin
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Inhibition caused by penicillin penicillin Reductionism
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Appropriate subjects? Untreatable ailments
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This note was uploaded on 05/30/2009 for the course SAS 30 taught by Professor Wilhelm during the Fall '08 term at UC Davis.

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Lecture twenty-one - Antibiotics Discovery Use in medicine 1928 England Alexander Fleming studied bacteria Bacterial cells Pure culture Fleming was

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