Lecture twenty-two 11 26 08

Lecture twenty-two 11 26 08 - Chemical modification...

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Penicillin V Chemical modification Penicillin G unstable in acid Intravenous Medical supervision Acid stable
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Penicillin V Chemical modification Penicillin G unstable in acid Intravenous Medical supervision Acid stable Taken as pills
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Penicillin – the first miracle drug Syphilis Septicemia – blood poisoning Strep throat / Scarlet fever Pneumonia Deaths caused by bacterial infections dropped by 95%
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Antibiotic resistance Extensive use in human medicine Consequence of: Natural selection for resistant strains
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Inappropriate use of antibiotics For a viral infection – cold or flu Prior to a diagnosis Failure to complete treatment Not taking all your pills
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Veterinary medicine: Preventative treatment High density animal populations Antibiotics prevent disease Antibiotic resistance A problem for people?
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Genes move between species Bacteria
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X X X No gene exchange between species
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Antibiotic resistance Human pathogens
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Penicillin inhibits cell wall synthesis Cell wall
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Enzyme degrades penicillin Penicillinase ANTIBIOTIC RESISTANCE
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PENICILLIN Penicillinase breaks the β –lactam ring
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Penicillinase de-activates penicillin SENSITIVE RESISTANT Penicillinase breaks the β –lactam ring
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This note was uploaded on 05/30/2009 for the course SAS 30 taught by Professor Wilhelm during the Fall '08 term at UC Davis.

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Lecture twenty-two 11 26 08 - Chemical modification...

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