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lecture 1 - BICD 100 Genetics Winter 2008 Andrew Chisholm...

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Lecture 1 8/1/08 Introduction to Genetics and Inheritance Heredity before Mendel Study of “generation” but no conception of heredity per se. Greeks (but not Aristotle): pangenesis; leads to Darwin s “gemmules” made by all cells, somehow influence gametes. Lamarck: animal s use or disuse of a character leads to its increase or decrease: Inheritance of Acquired Characteristics. Weissmann s distinction between germline and soma rules out Lamarckism but not until 1880s Mendel s Context Interest in animal and plant breeding coupled with mathematical training in Vienna Gartner, Kolreuter: establish that plants can reproduce sexually. Hybrids between two forms sometimes resemble one parent. “Identity of reciprocal hybrids”. “More variation” in next generation, but never quantitatively investigated. Mendel s Experimental Design 1. Use peas Pisum sativum; easily grown and allow controlled cross- and self-fertilization.
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