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Unformatted text preview: A company devises a test for the disease. The test has a 5% false positive rate, meaning 1 in 20 tests are positive when they should be negative (this is known as the test’s sensitivity, here 95%). The test does not give false negatives (the test’s specificity is 100%). If you test positive, what is the chance you actually have the disease? 3. An X-linked genetic disease can be transmitted from unaffected carrier mothers to affected sons, but can also arise from de novo mutation in the son’s X chromosome. For a given disease it has been shown that 2/3 of cases are inherited (transmitted from mother to son) and the remaining 1/3 are de novo . (a) A woman’s first child is an affected son. What is the probability that the woman is a carrier? (b) The woman has a second child, an unaffected son. What is the probability that the woman is a carrier? BICD100 Genetics Winter 2008 Chisholm...
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This note was uploaded on 05/31/2009 for the course BICD 100 taught by Professor Nehring during the Spring '08 term at UCSD.
- Spring '08