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Unformatted text preview: A company devises a test for the disease. The test has a 5% false positive rate, meaning 1 in 20 tests are positive when they should be negative (this is known as the test’s sensitivity, here 95%). The test does not give false negatives (the test’s specificity is 100%). If you test positive, what is the chance you actually have the disease? 3. An Xlinked genetic disease can be transmitted from unaffected carrier mothers to affected sons, but can also arise from de novo mutation in the son’s X chromosome. For a given disease it has been shown that 2/3 of cases are inherited (transmitted from mother to son) and the remaining 1/3 are de novo . (a) A woman’s first child is an affected son. What is the probability that the woman is a carrier? (b) The woman has a second child, an unaffected son. What is the probability that the woman is a carrier? BICD100 Genetics Winter 2008 Chisholm...
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This note was uploaded on 05/31/2009 for the course BICD 100 taught by Professor Nehring during the Spring '08 term at UCSD.
 Spring '08
 Nehring
 Genetics

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