12 steroid biosynthesis

12 steroid biosynthesis - Hormonal Properties Differ by...

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Hormonal Properties * Structure *   Mode of release *   How they move through blood *   Location of target receptors Differ by : *   Manner of affecting biological response
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Chemical Structure I.  Lipid-based  = prostaglandins II.  Monoamines  = containing single amino acid (a)  Catecholamines : [Adrenal Medulla] e.g. adrenaline, norephinephrine (b)  Indole amines e.g. melatonin, thyroid hormone *
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Chemical Structure III. Peptides or   Proteins – containing multiple a.a.  (a)  Peptide : <10 a.a.  [Hypothalamic hormones] e.g. TRH, CRF, GnRH, GHRH, somatostatin, ADH, & oxytocin (b)  Polypeptide : approx. 30 a.a. e.g. ACTH, calcitonin, insulin (c)  Protein : >> 50 a.a. e.g. prolactin, GH (d)  Glycoprotein : protein H + carbohydrate e.g. LH & FSH
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Chemical Structure I.V. Steroids  – derived from cholesterol (a)  Intact steroid nucleus   e.g. T, E (estriol ), P, & cortisol (b)  Broken steroid nucleus   e.g. vitamin D  & metabolites
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