20 Sex differnt2

20 Sex differnt2 - Differentiation of Internal Genitalia...

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Differentiation of Internal Genitalia Bipotential primordia  (e.g.  urogenital ridge -> gonads)   Indifferent stage lasts  approx 8 wk 1. Defeminization : regression  of Mullerian system due to  MIS  Separate primordia  (e.g. dual  2. Masculinization stimulation of Wolffian  system requires T
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Sexual Differentiation of External Genitalia Until 8th week of prenatal life : indifferent  stage, but with prominent  genital tubercle
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Indifferent External Genitalia External genitalia of both sexes arise from bipotential primordia: 1. Genital tubercle or glans area 2. Urogenital folds groove 3. Labioscrotal swellings - differentiate into penis or clitoris - envelop urethra - become labia or scrotum
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penile raphe incomplete  fusion =  hypospadia Virilization of Male Genitalia 2. Folds fuse over  groove to form  penile urethra. Line of closure  remains marked by  penile raphe . 1.
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This note was uploaded on 05/31/2009 for the course BAA 171 taught by Professor Drea during the Fall '07 term at Duke.

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20 Sex differnt2 - Differentiation of Internal Genitalia...

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