21 CAH & AI part 2

21 CAH & AI part 2 - Mutation impairs androgen...

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Masculinization of Female fused vagina Pseudo F Pseudo F Control F Control F Aggression (facial threat) Expt:  add  T  to pregnant rhesus carrying  XX fetus -> Pseudohermaphroditic F
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Congenital Adrenal Hyperplasia (CAH) 95% of cases involves enzyme  21  hydroxylase  deficiency
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labia
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CAH Behavioral Effects: Gender Role
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Androgen Insensitivity AI = most severe form of androgen resistance
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Unformatted text preview: Mutation impairs androgen receptor (AR) In 46 XY: * Blind vaginal pouch * Testes normal size (in abdomen or labia majora) * No Mullerian or Wolffian duct derivatives * Breast development * Scant axillary, pubic, & facial hair * Elevated levels of T * 5a reductase activity normal in peripheral tissues * Behaviorally identify as F...
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This note was uploaded on 05/31/2009 for the course BAA 171 taught by Professor Drea during the Fall '07 term at Duke.

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21 CAH & AI part 2 - Mutation impairs androgen...

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