exercise_2_solution

exercise_2_solution - Cellular and Molecular Neuroscience...

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Cellular and Molecular Neuroscience 2004 Exercise # 2 1) Match these cellular elements to their equivalent circuit elements: Resistor Lipid bilayer Capacitor Ionic concentration gradient Battery Ion channel Voltage source Transmembrane voltage 2) Imagine this circuit. There is a switch that can be flipped to connect or disconnect the voltage source to the rest of the circuit. What is the total current flow across the “membrane” right after the switch is thrown? What about 1 year after the switch is thrown? Can you write the full equation for the current flow as a function of time? Right after the switch is flipped, the total membrane current is: I m = C dV dt + g Na + V + g K + V After one year, probably all the charge is dissipated from the capacitor. Then: I m = ( g Na + + g K + ) V I in g Na+ g K+ C V
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3) What could you ever hope to understand by voltage-clamping a cell? One thing you can tell is the magnitude and time course of currents that are active when the cell is at a acertain voltage. If you think about what we learn from voltage clamp
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This note was uploaded on 05/31/2009 for the course NEURAL Stats taught by Professor Bauer during the Spring '09 term at NYU.

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exercise_2_solution - Cellular and Molecular Neuroscience...

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