Ceutics 2 emulsions (4).pptx - Emulsions Dr Doa’a Bashir...

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Emulsions Dr. Doa’a Bashir
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Emulsions Emulsion consists of 2 immiscible liquids, one is uniformly dispersed through the other as droplets (diameter > 0.1μm). To prepare a stable emulsion, a third phase is required→ Emulsifying agent. Oral emulsions are o/w and may contain one or more API. Useful for presenting oil and fat in palatable form. External emulsions (lotions, liniments, creams) can be w/o or o/w. **For internal use, when no other qualification is used, emulsions mean o/w.
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Pharmaceutical Applications of Emulsions Oral, rectal and topical adm. of oils and oil soluble drugs. Enhance palatability of oils when given orally. Can increase absorption of oils and oil soluble drugs through intestinal walls. IM injections of some water soluble vaccines to provide slow release and greater response. In total parenteral nutrition, to deliver oily nutrients intravenously to patients. * Examples: - Oral: Liquid paraffin, Castor oil emulsions. - External: Oily calamine lotion.
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Emulsion Types Oil in water (o/w) emulsions: Disperse phase: oil Continuous phase: water For oral or IV administration (always ). Water in oil (w/o) emulsions: Disperse phase: water Continuous phase: oil IM injections may be o/w or w/o. w/o Is used for a depot therapy. For external use: therapeutic use, texture and patient acceptability determine the needed type of emulsion.
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Multiple Emulsions: They are complex polydispersed systems where both o/w and w/o emulsion exists simultaneously which are stabilized by lipophillic and hydrophilic surfactants respectively. They can be w/o/w or o/w/o. Used for encapsulation of biactive drugs and for controlled release compounds (delayed action drug delivery).
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Identification of Emulsion Type (Tests) Miscibility test (Dilution test): An emulsion will mix with a liquid that is miscible with the continuous phase. Conductivity test: o/w systems will conduct electricity, while w/o systems won’t. Staining test (Cobalt chloride paper test): Filter paper soaked in cobalt chloride and dried turns from blue to pink on exposure to stable o/w emulsions. Dye test: If an water-soluble dye is used, w/o emulsions are paler in color than o/w emulsions and vice versa. Microscopically, w/o emul. will appear as colored globules on a colorless background while o/w emul. will appear as colorless globules on a colored background.
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Miscibility test (Dilution test) Conductivity test Staining test Dye test
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Formulation of Emulsions The formulation of emulsions involves the prevention of coalescence of the disperse phase and reducing creaming. Emulsifying agents - Help the production of a stable dispersion be reducing interfacial (surface) tension and then maintaining the separation of droplets by forming a barrier at the interface.
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  • Fall '19
  • Emulsion, Primary Emulsion

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