Week 6 DiscussionTanisha FlowersWalden UniversityAdvanced PharmacologyDr. Funda TiryakiApril 6, 2016Osetoarthritis (OA) is a common, progressive disease that can result in chronic pain affecting the joints.There are twoforms. Primary or idiopathic resulting from physiologic changes that occur with normal aging and secondary OA resultingfrom traumatic injuries or inherited conditions (Arcangelo & Peterson, 2013). Cartilage undergoes a remodeling process,stimulated by joint movement or use. In OA, this process is altered by a combination of mechanical, cellular, biochemicalprocesses, resulting in abnormal reparation of cartilage and an increase in cartilage degradation (Dewing, Setter, &Slusher, 2012).OA is characterized by local areas of loss and damage of articular cartilage, new bone formation of jointmargins, subchondral bone changes variable degrees of mid synovitis, and thickening of the joint capsule (Huether &McCance, 2012).