{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

3254085356(2)

3254085356(2) - 1 BIOL105ProblemSet#8 KEY Name DS TA...

Info icon This preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
BIOL105 - Problem Set #8 KEY Name _______________________ DS # _______________________ TA ______________________ Textbook problems: Chapter 19: Social and Ethical Issues 1-3, Solved Problem 1, Problems 1, 5, 6, 9, 10, 11, 15, 17, 18, 19, 23 Reference C - look over Solved Problem II, Problems C-3, C-4, C-6 - none are particularly useful for what we focused on in class "For credit" problems are due Monday, June 2 by 9:30 am. 1) There are both hereditary forms and sporadic (non-hereditary) forms of some cancers, such as retinoblastoma, colon cancer, and breast cancer. Briefly explain the basis for the hereditary form of such diseases and contrast it to the sporadic form. Explain why the hereditary form of each disease behaves as a dominant trait in pedigree analysis. The hereditary form of some cancers is due to the inheritance of a mutated copy of a tumor-suppressor gene (e.g. Rb for retinoblastoma) from a parent. All cells in the individual carry one mutant copy and one wild-type copy of the tumor-suppressor gene. A mutation in the wild-type copy of the tumor-suppressor gene in a cell (a retinal cell in the case of retinoblastoma) creates a homozygous mutant cell, which then develops into a tumor (an eye tumor in the case of retinoblastoma). Sporadic forms of the same cancers require two mutations in the same tumor suppressor gene in the same cell. Such a double hit in the same gene in the same cell occurs relatively rarely. The dominant behavior of inherited mutations in TSGs must mean that accumulating the other mutations that lead to cancer will happen with a very high probability in at least 1 cell of the individual. 1
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2) In liver cells, the product of the “plf” gene stimulates cell proliferation in response to mitogenic (i.e. mitosis-inducing) signals, the product of the “inh” gene inhibits progression through the cell cycle until conditions are favorable, and the product of the "apo" gene promotes apoptosis in response to damage. Liver cancer is caused by mutational events in all 3 genes .
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern