3254085356(2) - 1 BIOL105ProblemSet#8 KEY Name_ DS#_ TA _...

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BIOL105 - Problem Set #8 KEY Name _______________________ DS # _______________________ TA ______________________ Textbook problems: Chapter 19: Social and Ethical Issues 1-3, Solved Problem 1, Problems 1, 5, 6, 9, 10, 11, 15, 17, 18, 19, 23 Reference C - look over Solved Problem II, Problems C-3, C-4, C-6 - none are particularly useful for what we focused on in class "For credit" problems are due Monday, June 2 by 9:30 am. 1) There are both hereditary forms and sporadic (non-hereditary) forms of some cancers, such as retinoblastoma, colon cancer, and breast cancer. Briefly explain the basis for the hereditary form of such diseases and contrast it to the sporadic form. Explain why the hereditary form of each disease behaves as a dominant trait in pedigree analysis. The hereditary form of some cancers is due to the inheritance of a mutated copy of a tumor-suppressor gene (e.g. Rb for retinoblastoma) from a parent. All cells in the individual carry one mutant copy and one wild-type copy of the tumor-suppressor gene. A mutation in the wild-type copy of the tumor-suppressor gene in a cell (a retinal cell in the case of retinoblastoma) creates a homozygous mutant cell, which then develops into a tumor (an eye tumor in the case of retinoblastoma). Sporadic forms of the same cancers require two mutations in the same tumor suppressor gene in the same cell. Such a double hit in the same gene in the same cell occurs relatively rarely. The dominant behavior of inherited mutations in TSGs must mean that accumulating the other mutations that lead to cancer will happen with a very high probability in at least 1 cell of the individual. 1
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2) In liver cells, the product of the “plf” gene stimulates cell proliferation in response to mitogenic (i.e. mitosis-inducing) signals, the product of the “inh” gene inhibits progression through the cell cycle until conditions are favorable, and the product of the "apo" gene promotes apoptosis in response to damage. Liver cancer is caused by mutational events in all 3 genes . What genotypes for the 3 genes would you expect to see in liver-cancer cells undergoing
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This note was uploaded on 06/05/2009 for the course BIO 105 taught by Professor Sullivan during the Spring '08 term at University of California, Santa Cruz.

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3254085356(2) - 1 BIOL105ProblemSet#8 KEY Name_ DS#_ TA _...

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