lecture_25_notes

lecture_25_notes - Lecture 25 Gene structure in eukaryotes...

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Lecture 25 Gene structure in eukaryotes Virtually all prokaryotic genes are organized in an ORF that starts with an ATG, exhibits a continuous reading frame and terminates with a STOP codon. Once the first eukaryotic genes were isolated and sequenced, it was found that they were more complex than the prokaryotic ones. A typical eukaryotic gene is shown below: like the typical prokaryotic gene it consists of a pro- moter, a transcribed region, and a transcription termination region (not shown in the drawing). Different from the bacterial gene, both promoters and transcribed regions are more complex. The promoter has a polymerase entry site called the TATA box, which is comparable to the prokaryotic -12 and -35 regions. The TATA box is about -20 to -30 from the transcriptional start. The promoter has also other regions to which regulatory proteins bind (more later if we have time). More surprising than the complex promoter was the finding that many genes are not continu-
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lecture_25_notes - Lecture 25 Gene structure in eukaryotes...

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