lecture_19_notes - Lecture 19 Linkage Finish Linkage: The...

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Lecture 19 Linkage Finish Linkage: The frequency of recombination is used as a measure of distance between A and B. This is the called the "genetic distance". The unity of distance are centiMorgans (~100 x # recom- binants/ (recombinants + parentals) Locus: a position on a chromosome, typically meant in the context of the a gene. For exam- ple, the wrinkled locus of pea. Pl. loci. Recombination frequencies between loci can be measured and used to assemble a map example: W-T = 20, W-Y = 10, Y-T = 30 makes a map: Y_10_W___20___T Alleles and gene function Alleles are different forms of a gene The wild-type allele is defined as the one found most frequently in a natural population Natural population: individuals of the same species in a natural environment. Example: Pop- pies in a meadow, grasses of a species in a prairie, Red-winged blackbirds around Davis, a human tribe in New Guinea Typically, the wild-type allele has good function. Different alleles arise continuously by mutation. Mutants, individuals in which a gene has changed in structure, arise at a frequency of 1/million - 1/100 millions per gene per generation. Given that most species have 20,000 to 40,000 different genes, the probability of carrying a re- cently formed mutation is very high for any individuals Mutations arise from multiple types of errors, typically in replication of DNA, and can involve
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This note was uploaded on 06/07/2009 for the course BIS BIS2A taught by Professor Lucacomai during the Spring '09 term at UC Davis.

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lecture_19_notes - Lecture 19 Linkage Finish Linkage: The...

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