lecture_13_notes

lecture_13_notes - Lecture 13 Cell division (continued) The...

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Lecture 13 Cell division (continued) The eukaryotic chromosome (chromo=color, some=body) Structure: a single, linear dsDNA molecule, complexed with many proteins (DNA + protein = chromatin). Carries genes. Depending on the organism size of chromosomes varies from ~1 million (Mega, M) base pairs (bp) to more than 1000 M (i.e. a Giga, G) bp. Multiple chromosomes (2 - 100s) per species. Human has 46 chromosomes. Chr 1 is 246 Mb. Chr 21 is 46 Mb. Arabidopsis (a weed) has 10 chromosomes. Rice has 12 chromosomes. During G1 phase the chromosome is a nearly invisible thread. At the beginning of S phase, DNA replication initiates at many "origins". Replication bubbles expand from origin to eventually cover all chromosome At the end of S phase the chromosome is formed of 2 dsDNA molecules tightly held together by specialized proteins. The duplicated chromosome is still ONE single chromosome, made of TWO chromatids. Summarizing the number of paired strands of DNA, and number of ds DNA threads per
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This note was uploaded on 06/07/2009 for the course BIS BIS2A taught by Professor Lucacomai during the Spring '09 term at UC Davis.

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lecture_13_notes - Lecture 13 Cell division (continued) The...

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