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Unformatted text preview: 7. Check orientation of force transducer BEFORE tying gut segment to transducer (contractions should produce an increase in tension on the monitor) 8. Watch for data clipping! Need to anticipate the expected changes in tension and set baseline appropriately BEFORE adding an experimental substance a. Epinephrine decrease intestinal motility (baseline should be set near the top of the screen) b. Methacholine increase intestinal motility (baseline should be set near the bottom of the screen) c. ADP decrease intestinal motility (baseline should be set near the top of the screen) d. NOTE: changes in intestinal motility may be manifested in 3 ways: (1) changes in amplitude of contractions, (2) changes in frequency of contraction, and (3) changes in baseline tension e. If data gets clipped, you will need to Full-Scale knob and NOTE the time at which the Full-Scale knob was changed (use event marker) Sassan Rafizadeh F2007...
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- Spring '08