GImotility

GImotility - NPB101L Section 2 TA: Jen Lee Lab 8:...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
NPB101L Section 2 TA: Jen Lee Lab 8: Intestinal Motility Gastrointestinal smooth muscle: 2 major layers of smooth muscle - Outer longitudinal Inner circular Characteristics and mechanisms… Not striated, misalignment of actin and myosin; unitary type Follows sliding filament theory – contraction due to translocation of actin filaments relative to myosin filaments, get cross-bridging using ATP and Ca2+ Force is transmitted/conducted by extracellular connections with fibers of collagen that function as an intramuscular tendon Dense bodies: sites of attachment of actin to plasma membrane and extracellular matrix protein Smooth Muscle Excitation-Contraction Coupling Regulated by thick-filament linked mechanism ↑ [Ca 2+ i ] activates MLCK phosphorylates regulatory light chain myosin Primary site of regulation by Ca 2+ = thick filament myosin Contraction initiated by membrane depolarization = ↑ [Ca 2+ i ]
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 06/07/2009 for the course NPB 101L taught by Professor Goldberg during the Spring '08 term at UC Davis.

Page1 / 3

GImotility - NPB101L Section 2 TA: Jen Lee Lab 8:...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online