xs96498 - $517 0 11‘1"" VM-PMI 126 2nd...

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Unformatted text preview: $517 0 11‘1"" VM-PMI 126 2nd MIDTERM 2000 U560 > l. The major histocompatibility complex is: a) A complex of genes that encodes the TCR and Ig genes b) A single gene that encodes class 1 proteins c) A single gene that encodes class 2 proteins (1) A complex of genes that encodes adhesion proteins expressed on leukocytes e) None of the above 2. The human MHC is referred to as HLA a) True b) False 3. Which of the following refer to genes encoding human MHC class 2 proteins? a) DP genes b) HLA-A genes 0) DQ genes (1) Two of the above e) All of the above 4. Which of the following refer to MHC class 2 protein expression? a) They are expressed on most nucleated cells b) They are expressed on follicular dendritic cells c) They present predominantly endogenous antigen d) Two of the above e) None of the above 5. Which of the following would you associate with a MHC class 1 protein a) Expressed on most nucleated cells b) Expressed on follicular dendritic cells c) Present predominantly endogenous antigen d) Two of the above e) None of the above 6. MHC class I and 11 proteins function as a capture and display system for antigens (peptides). a) True b) False 10. 11. If a macrophage were to ingest a bacteria that was killed by complement- mediated lysis, would the bacterial antigens be presented primarily by a) TCR b) SIg c) MHC 1 protein (1) MHC 2 protein e) All of the above Do polymorphic residues in the MHC class 1 protein reside in a) The or chain b) [52 microglobulin c) The v chain (1) Two of the above e) All of the above Which of the following are true of MHC class 1 proteins a) They present endogenous antigen b) They are transported to the cell membrane only after they have been loaded with peptide c) TAP 1 and TAP 2 play a role in loading them with peptide d) All of the above are correct e) None of the above are correct Where do MHC class 2 proteins get loaded with peptide? a) Endoplasmic reticulum b) Endosomal compartment c) Nucleus d) All of the above e) None of the above A population (species) of animals (elephant seals) went through a genetic bottle-neck (were reduced to very few animals) in the early 1900’s. Which of the following would you expect to find in the re-established population, as compared to the original (pre-bottleneck) large population? a) A reduction in the diversity of TCR b) A reduction in the diversity of immunoglobulin c) A reduction in the diversity of MHC 1 and 2 genes d) None of the above e) All of the above 12. 13. 14. 15. 16. 17. Peptides that bind to MHC class 2 proteins typically must have the appropriate anchor residues in the carboxy- and ammo-terminal ends. a) True b) False Peptides that bind to MHC class 1 proteins are typically 8 to 10 amino acids long. Since the peptide-binding cleft is closed at both ends, a peptide of greater length could not easily be accomodated! a) True b) False Which of the following would be true of an immature T lymphocyte in the thymus? a) Might express a TCR b) Might express surface Ig c) Might express both CD4 and CD8 simultaneously d) Two of the above e) All of the above Which of the following lymphocytes are MHC-restricted? a) alpha-beta T cells b) gamma-delta T cells c) NK cells d) Two of the above e) All of the above TCR receptor diversity is created via gene rearrangement. When the alpha chain genes rearrange, the delta chain genes are eliminated from the germline of that cell. a) True b) False Gamma-delta T cells can generate extensive variability in their TCR’s. Which of the following can contribute to this process? a) Addition of N nucleotides b) Combinatorial VJ and VDJ joining c) Utilizing more than one D region gene in a single TCR d) Two of the above e) All of the above 18. 19. 20. 21. 22. 23. Alpha—beta T lymphocytes mature and gain a functional TCR in which of the following tissues? a) Bone marrow b) Spleen c) Thymus d) Lymph node e) None of the above Which of the following is true of alpha-beta T lymphocyte education? a) Results in affinity maturation of the TCR b) Occurs in the bone marrow 0) May result in selection of cells that can interact to some degree with self MHC and foreign peptide d) Two of the above e) None of the above A maturing T lymphocyte might express which of the following proteins on the cell surface? a) CD3 b) TCR c) CD4 (1) Two of the above e) All of the above Negative selection refers to the elimination of T lymphocytes that have not successfully rearranged TCR genes. a) True b) False After engagement of the TCR, the alpha chain is responsible for signal transduction. a) True b) False A mature T lymphocyte expresses a variety of cell surface adhesion proteins, many of which bind their ligand in an antigen-specific manner a) True b) False 24. Which of the following is true of CD3? a) Can be composed of up to 5 different protein chains b) Is only expressed on T lymphocytes with a TCR c) Is involved in signal transduction 25. 26. 27. 28. d) Two of the above are true e) All of the above are true Which is the ligand for TCR a) CD28 b) B7 c) Peptide that is bound to MHC d) MHC 2protein e) None of the above Which is the ligand for CD3 a) CD28 b) B7 c) Peptide that is bound to MHC d) MHC 2 protein e) None of the above Which is the ligand for CD28 a) CD28 b) B7 c) Peptide that is bound to MHC d) MHC 2 protein e) None of the above Which is the ligand for CD4 a) CD28 b) B7 c) Peptide that is bound to MHC d) MHC 2 protein C) None of the above 29. 30. 31. 32. 33. Which is the ligand for CD8 a) CD28 b) B7 c) Peptide that is bound to MHC d) MHC 2 protein e) None of the above Engagement of CD28, CD4, CD8, CD2 or LFA-l (CD1 la/l 8) on the T cell with their respective ligands on an APC or target cell can result in which of the following? a) Signal transduction in the T cell b) Adhesion of the T cell with an APC or target cell c) Cause activation of the complement cascade d) Two of the above e) All of the above A nieve T lymphocyte can become anergic if it’s TCR binds peptide-MHC in the absence of sufficient signal transduction. a) True b) False T cell anergy refers to a T lymphocyte that has been induced to undergo apoptosis. a) True b) False Which of the following might be true of MHC class 2 genes and/or their encoded proteins? a) Have multiple alleles/locus b) Different beta chain gene products can associate with the same alpha chain gene products c) Both alleles (maternal and paternal) are co-dominantly expressed (1) None of the above e) All of the above 34. 35. 36. 37. 38. 39. 40. After alpha chain gene rearrangement, the T cell can continue to proliferate prior to rearrangement of the beta chain, resulting in the generation of T lymphocytes that share a single alpha chain but have different antigen specificities due to the use of different beta chains. a) True b) False Cytokines can act in which of the following ways? a) Autocrine b) Paracrine c) Endocrine d) All of the above e) None of the above Interleukine 2 is a major T cell growth factor. a) True b) False Interleukin 4 is associated with B lymphocytes undergoing an antibody class switch to IgE a) True b) False Interleukin 12 is produced by macrophages and can help activate T lymphocytes. a) True b) False Gamma interferon is important in macrophage activation. a) True b) False Gamma interferon can inhibit THl lymphocytes while interleukin 4 can inhibit TH2 lymphocytes. a) True b) False 41. 42. 43. 44. 45. T independent antigens typically induce B cell responses of the following isotypes? a) lgE b) IgG c) IgM (1) IgA c) All of the above During the initiation of a first exposure to an antigen, which of the following cells would you expect to be the most important APC for nieve T-helper cells? a) lemphocytes b) B lymphocytes c) Macrophages d) Follicular dendritic cells e) Thymic epithelial cells Which of the following can activate the complement system a) IgM-antigen complex b) IgE-antigen complex c) IgG-antigen complex d) Two of the above e) All of the above Which of the following complement fragments are anaphylatoxins a) C5b6789 b) C3b c) CSa d) C1qr&s e) None of the above Which of the following complement fragments represent the membrane attack complex? a) C5b6789 b) C3b c) C5a d) C1qr&s e) None of the above 46. 47. 48. 49. 50. Which of the following complement fragments can be major opsonins? a) C5b6789 b) C3b c) C5a d) C1qr&s e) None of the above Can the complement system be activated in the absence of an antibody- antigen complex being formed? a) Yes b) No B lymphocytes can express a cell surface protein called CD21, also known as CR2. Which of the following are true as regards this protein? a) Can interact in a receptor-ligand interaction with CD2 on T lymphocytes b) Can interact in a receptor-ligand interaction with some fragments of complement c) Can interact in a receptor—ligand interaction with CD4 d) Two of the above are correct e) All of the above are correct Gram positive bacteria are more sensitive to complement mediated lysis than are gram negative bacteria. a) True b) False Which of the following typically occur following the classical activation of the complement cascade? a) Production of inflammatory mediators b) Opsonization of the antigen c) Amplification of the cascade via activity of the C3 convertase (1) Two of the above are correct e) All of the above are correct ...
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This note was uploaded on 06/07/2009 for the course PMI 126 taught by Professor Stott,jeffrey during the Winter '08 term at UC Davis.

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