2a Infrared Spectroscopy and Analgesic Drug Identification

2a Infrared Spectroscopy and Analgesic Drug Identification...

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2a Infrared Spectroscopy and Analgesic Drug Identification Author: Holly Polk Instructor: Oleksandr Zhurakovskyi Organic Chemistry Lab 243A, Section 010 Date Work Performed: February 5 , 2009 Date Submitted: February 12, 2009 Abstract The objective of the Infrared Spectroscopy and Analgesic Drug Identification is to isolate and identify Acetylsalicylic Acid by the melting point, percent recovery, Rf value and weight. The manufacturer’s amount of active ingredient was 325 mg. After the isolation of the active ingredient there was 179 mg of pure material. The percent recovery was 55.07% and the melting point was 125 degrees Celsius, which was ten degrees different than the standard melting point of ASA, or 135 degrees C. When TLC was performed, the Rf values of the manufacturer and sample were both 0.60.
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Introduction The purpose of the lab is to identify the active ingredient of an analgesic drug and use an infrared spectrum. The lab will begin with extraction, filtration, and lastly spectroscopic identification. Infrared spectroscopy is used for qualitative identification of organic compounds. This is possible because molecules are flexible, moving collections of atoms, and atoms are constantly oscillating around average positions. Bond lengths and bond angles are continuously changing due to this vibration. A molecule absorbs infrared radiation when the vibration of the atoms in the molecule makes an oscillating electric field with the same frequency as the frequency of incident IR "light". A molecule absorbs a unique set of IR light frequencies, so observation and comparison allows for identification. Different functional groups correspond to specific absorption peaks. Infrared spectroscopy will give a graphical display for a molecule. It shows the frequencies of IR radiation absorbed and the % of the incident light that passes through the molecule without being absorbed. The spectrum has two regions. The fingerprint region (1600-600cm -1 ) is unique for a molecule and the functional group region is similar for molecules with the same functional groups. If the unknown molecule was Acetylsalicylic acid, the spectrum would show signs of an acid. First, look for indications that an O-H is also present. It has a broad absorption near 3300- 2500 cm -1 . This actually will overlap the C-H stretch. There will also be a C-O single bond band near 1100-1300 cm -1 . Also, look for the carbonyl band near 1725-1700 cm -1 . Basically, looking at all wavelengths will demonstrate the compound’s identity.
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Physical Constants Compound name Structure Molecu lar weight * mp Which brands contain the ingredient? Safety
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2a Infrared Spectroscopy and Analgesic Drug Identification...

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