1_15_09_HodgkinHuxley

1_15_09_HodgkinHuxley - This circuit’s function depend on...

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Unformatted text preview: This circuit’s function depend on nonlinear synaptic mechanisms. Today, we will focus on models for action potentials. Equivalent-circuit models for action potentials are RC circuits with many conductances. c m dV dt = ! i m + I e A If A is the membrane surface area, c m is the capacitance per unit area, and i m is the sum of all membrane currents per unit area, then i m = g L V ! E L ( ) + g K n 4 V ! E K ( ) + g Na m 3 h V ! E Na ( ) Disregarding synapses (g s ), and making n , m , and h the probabilities of opening of activation and inactivation of voltage-dependent gates, the Hodgkin-Huxley model is One can conceptualize these gates in molecular terms. A. K + channel B. Na + channel Individual channels are all-or-none and have random opening times. c m dV dt = ! i m + I e A If A is the membrane surface area, c m is the capacitance per unit area, and i m is the sum of all membrane currents per unit area, then i m = g L V ! E L ( ) + g K n 4 V ! E K ( ) + g Na m 3 h V ! E Na ( ) Disregarding synapses (g...
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This note was uploaded on 06/08/2009 for the course BME 575L taught by Professor Grzywacz during the Spring '09 term at USC.

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1_15_09_HodgkinHuxley - This circuit’s function depend on...

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