1_20_09_Gating

1_20_09_Gating - One can conceptualize these gates in...

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Unformatted text preview: One can conceptualize these gates in molecular terms. A. K + channel B. Na + channel The K + channel has one open and four closed states with probabilistic transitions given by a n and b n from the Hodgkin-Huxley model. The K + channel has one open and four closed states with probabilistic transitions given by a n and b n from the Hodgkin-Huxley model. ! p 1 = ! n p 2 " 4 # n p 1 ! p 2 = 4 # n p 1 + 2 ! n p 3 " ! n + 3 # n ( ) p 2 ! p 3 = 3 # n p 2 + 3 ! n p 4 " 2 ! n + 2 # n ( ) p 3 ! p 4 = 2 # n p 3 + 4 ! n p 5 " 3 ! n + # n ( ) p 4 ! p 5 = # n p 4 " 4 ! n p 5 The probability of being at state i (which has 4- (i-1) close gates and i-1 open gates) obeys These equations reflect independence of gates, similar to Hodgkin-Huxley’s n 4 dependence. Independence One can conceptualize these gates in molecular terms. A. K + channel B. Na + channel One can conceptualize these gates in molecular terms. A. K + channel B. Na + channel No independence; inactivation can only occur after activation gate opens. This model is different from Hodgkin-Huxley’s, because the transition to the inactive state is state dependent and independent of voltage. state dependent and independent of voltage....
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1_20_09_Gating - One can conceptualize these gates in...

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