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Unformatted text preview: One can conceptualize these gates in molecular terms. A. K + channel B. Na + channel The K + channel has one open and four closed states with probabilistic transitions given by a n and b n from the HodgkinHuxley model. The K + channel has one open and four closed states with probabilistic transitions given by a n and b n from the HodgkinHuxley model. ! p 1 = ! n p 2 " 4 # n p 1 ! p 2 = 4 # n p 1 + 2 ! n p 3 " ! n + 3 # n ( ) p 2 ! p 3 = 3 # n p 2 + 3 ! n p 4 " 2 ! n + 2 # n ( ) p 3 ! p 4 = 2 # n p 3 + 4 ! n p 5 " 3 ! n + # n ( ) p 4 ! p 5 = # n p 4 " 4 ! n p 5 The probability of being at state i (which has 4 (i1) close gates and i1 open gates) obeys These equations reflect independence of gates, similar to HodgkinHuxleys n 4 dependence. Independence One can conceptualize these gates in molecular terms. A. K + channel B. Na + channel One can conceptualize these gates in molecular terms. A. K + channel B. Na + channel No independence; inactivation can only occur after activation gate opens. This model is different from HodgkinHuxleys, because the transition to the inactive state is state dependent and independent of voltage. state dependent and independent of voltage....
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 Spring '09
 Grzywacz

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