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Unformatted text preview: Outline of the Lecture Outline of the Lecture Modeling Channels Modeling Channels Multiple States Ionotropic Conductances Multiple States Ionotropic Conductances NMDA NMDA Models of Channels Have Models of Channels Have Multiple Probabilistic States Multiple Probabilistic States and Transitions and Transitions One can conceptualize these gates in molecular terms. A. K + channel B. Na + channel The K + channel has one open and four closed states with probabilistic transitions given by α n and β n from the HodgkinHuxley model. The K + channel has one open and four closed states with probabilistic transitions given by α n and β n from the HodgkinHuxley model. & p 1 = β ν π 2 4 α ν π 1 & π 2 = 4 α ν π 1 + 2 β ν π 3 β ν + 3α ν ( 29 π 2 & π 3 = 3α ν π 2 + 3 β ν π 4 2 β ν + 2 α ν ( 29 π 3 & π 4 = 2 α ν...
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 Spring '09
 Grzywacz
 NMDA, A. K+ channel, K+ channel B., channel B. Na+

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